Inflammatory mediators in skin

"Inflammatory mediators in skin" is not a single molecular entity but rather refers to a **diverse group of molecules** produced by various cell types within the skin—including keratinocytes, mast cells, macrophages, T cells, sebocytes and others—that regulate immune responses and tissue homeostasis. These include **cytokines** (such as interleukins IL‑1α/β and TNF‑α), **chemokines**, **growth factors**, **antimicrobial peptides** (like LL‑37 and β-defensins), **lipid-derived molecules** (eicosanoids), neuropeptides (**substance P**, CGRP), matrix metalloproteinases (**MMPs**) and more[1][2][4][5]. They orchestrate processes such as recruitment of immune cells after injury or infection[2], modulation of keratinocyte behavior[4], angiogenesis regulation[2], pain/itch signaling via neuronal activation[1], tissue repair/remodeling[4], polarization of adaptive immunity [5] and maintenance/disruption of barrier function. Dysregulation leads to pathological conditions including chronic inflammation seen in diseases like psoriasis or impaired wound healing. Because this term encompasses many distinct targets with different roles/mechanisms—and is not itself a discrete protein/receptor/enzym—it is not considered an actionable therapeutic target per se.

Other names

Inflammatory mediators in the skinSkin inflammatory mediatorsCutaneous inflammatory mediators