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Target intelligence / Profile preview
Inflammatory Mediators in Tear Film
- Molecular classification
- Cytokine, Chemokine, Growth Factor, Lipid Mediator, Protease, Protease Inhibitor
01
Overview
Inflammatory mediators in the tear film are a diverse group of molecules central to regulating immune responses on the ocular surface—serving both physiological defense roles and contributing pathologically when overexpressed during diseases like dry eye or keratoconus.
- Other names
- Tear film inflammatory mediatorsOcular surface inflammatory mediators
02
Mechanism of action
Inhibition of T-cell activation/pro-inflammatory cytokine release; Suppression of mediator release
03
Biological functions
Immune cell recruitmentEpithelial cell apoptosis/survival regulationGoblet cell density modulationExtracellular matrix remodelingVascular permeability regulationImmune responseInflammation
04
Disease associations
Dry Eye DiseaseContact lens-related inflammationKeratoconusOcular surface disordersInflammation
05
Safety considerations
Potential for immunosuppressionSide effects associated with corticosteroids (e.g., glaucoma, cataract formation)
06
Interacting drugs
Cyclosporine A
1 more in the full profile.
07
Biomarkers
IL-1βIL-2IL-4IL-5IL-6IL-8 (CXCL8)IL-10IL-13TNF-αIFN-γGM-CSFLTB4MMP-9TIMPs
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