Inflammatory pathway in skin

The term "inflammatory pathway in skin" refers collectively to a network of cellular and molecular mechanisms that mediate inflammation in cutaneous tissues. These involve numerous cell types—including keratinocytes, immune cells like macrophages and neutrophils—and key mediators such as cytokines (e.g., interleukins), chemokines, growth factors, and transcription factors like NF-kappaB and STAT proteins[2][3]. Activation occurs when pattern recognition receptors detect harmful stimuli or injury; this triggers cascades leading to release of pro-inflammatory mediators that recruit additional immune cells[3]. Chronic dysregulation is implicated in diseases such as psoriasis and atopic dermatitis. While many drugs modulate components within these pathways—such as inhibitors targeting TNF-alpha or JAK/STAT—the "inflammatory pathway in skin" itself is not a discrete therapeutic target but an umbrella term encompassing many potential drug targets[2][3].

Other names

Skin inflammatory signalingCutaneous inflammatory pathwaysInflammatory response in skin