Inflammatory pathway signaling proteins

Inflammatory pathway signaling proteins include a variety of molecular components that transmit and regulate signals driving inflammation in cells and tissues. These comprise enzymes (such as kinases), transcription factors (NF-κB, AP-1), adaptor proteins (e.g., MAL/TIRAP), innate immune receptors (TLRs), cytokines, and multi-protein complexes (inflammasomes). Collectively, these proteins orchestrate the detection of pathogens or damage, the release of inflammatory mediators, and the recruitment/activation of immune cells. Dysregulation of these protein-mediated signaling events contributes to the pathogenesis of numerous chronic, infectious, and autoimmune diseases. Many are validated or potential targets for anti-inflammatory drugs, but due to redundancy in pathways and widespread physiological roles, therapeutic intervention carries risks including immune suppression and collateral effects on tissue homeostasis[1][2][3][4][5][6][7][8][9].

Other names

Pro-inflammatory signaling proteinsInnate immunity signaling proteinsInflammatory mediatorsCytokine signaling proteins

Inhibition of kinase activity (blocking IκB kinase, MAP kinases) Interference with adaptor-receptor interactions (disrupting MAL-PKCδ, MAL-c-Jun) Suppression of transcription factor activation (inhibiting NF-κB or AP-1 translocation)