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Inflammatory Pathways: Cytokines and Chemokines
- Molecular classification
- Cytokine, Chemokine, Interleukin (IL), Tumor Necrosis Factor (TNF), Interferon (IFN), Colony Stimulating Factor (CSF), Transforming Growth Factor (TGF), CC chemokine, CXC chemokine, CX3C chemokine, XC chemokine, G protein-coupled receptor (chemokine receptors), Transmembrane protein complex (cytokine receptors)
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Overview
Inflammatory pathways involving cytokines and chemokines refer to the complex network of signaling proteins that regulate immune cell recruitment, activation, and function during inflammation. These molecules are central to both initiating and resolving inflammatory responses in the body. Cytokines act as chemical messengers, regulating immune cell behavior and mediating both pro- and anti-inflammatory effects. Chemokines primarily direct cell migration, especially leukocytes, to sites of infection or injury. Dysregulation in these pathways is implicated in various diseases, making them therapeutic targets for modulating inflammation.
- Other names
- CytokinesChemokinesInflammatory mediators
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Mechanism of action
Blocking pro-inflammatory mediators, enhancing anti-inflammatory signals
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Biological functions
Regulation of immune responseInitiation of inflammationResolution of inflammationCell signalingImmune cell recruitmentImmune cell activationChemotaxisLeukocyte adhesionHomeostasis in lymphoid tissues
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Disease associations
Autoimmune diseasesChronic inflammatory conditionsNeuroinflammationNeurodegenerative diseaseSepsisCytokine storm syndromes
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Safety considerations
Cytokine stormsExcessive inflammationTissue damageDysregulated immune response
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