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Inflammatory Protein Substrate

Molecular classification: Protein

Overview

An inflammatory protein substrate is any protein that is specifically recognized and cleaved by inflammatory proteases (primarily the inflammatory caspases) during immune responses. Cleavage of these substrates leads to downstream effects such as cytokine maturation or induction of cell death pathways like pyroptosis. Well-known examples include Gasdermin D (GSDMD), Interleukin 1 beta (IL-1β), and Interleukin 18 (IL-18).

Biological functions

Cytokine maturation/releaseInduction of pyroptosisImmune response

Disease associations

Inflammation

Safety considerations

Potential for pathological inflammation if dysregulated

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