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Target intelligence / Profile preview
Inflammatory Response via MicroRNA Regulation (miRNA-Inflammation)
- Target
- miRNA-Inflammation
- Molecular classification
- Regulatory network, MicroRNA, Non-coding RNA, Gene regulatory element
01
Overview
The inflammatory response, regulated by microRNAs (miRNAs), is a complex physiological reaction to harmful stimuli. miRNAs modulate gene expression at the post-transcriptional level, playing a crucial role in immune cell development, activation, and signaling pathways. They regulate inflammation through altered expression in immune cells during initiation, expansion, and resolution, exerting both positive and negative feedback. Dysregulation of inflammatory-related miRNAs is implicated in various diseases, making them potential therapeutic targets for modulating pathological inflammation.
- Other names
- miRNA regulation of inflammationInflammation regulated by microRNAsmiRNA-mediated inflammatory response
02
Mechanism of action
Post-transcriptional repression or degradation of target mRNAs through microRNA binding.
03
Biological functions
Immune responseGene regulationPost-transcriptional regulationInflammation modulationHomeostasis maintenancePathogen defenseTissue repair
04
Disease associations
Chronic inflammationAutoimmune disordersCancerWound healingInfection
05
Safety considerations
Off-target effects of miRNA mimics/inhibitorsPotential for unintended immune suppression or activationDelivery challenges for miRNA therapeutics
06
Interacting drugs
Synthetic microRNA mimics
1 more in the full profile.
07
Biomarkers
miR-155miR-146miR-21miR-181bmiR-223miR-142
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