Inflammatory Signaling Receptor (N/A)

Inflammatory signaling receptors comprise several major families that sense danger signals or endogenous cues. They activate overlapping but distinct intracellular networks controlling the magnitude/duration/type of inflammation. Their dysfunction is implicated in numerous acute/chronic diseases due to excessive or insufficient control over these critical processes. These include Pattern Recognition Receptors (PRRs), Cytokine Receptors, G Protein-Coupled Receptors (GPCRs), Fc Receptors, and the Receptor for Advanced Glycation End Products (RAGE). These receptors detect harmful stimuli or tissue injury, activate intracellular signaling cascades, induce expression/release of inflammatory mediators such as cytokines, recruit immune cells via chemotaxis and regulate processes like phagocytosis or programmed cell death.

Other names

Pattern Recognition ReceptorsCytokine ReceptorsG Protein-Coupled ReceptorsFc ReceptorsReceptor for Advanced Glycation End ProductsPRRsGPCRsRAGE