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Target intelligence / Profile preview
Influenza A H3N2 Hemagglutinin Protein (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral Surface Protein
01
Overview
The hemagglutinin (HA) protein is a major surface glycoprotein of the Influenza A virus, specifically in the H3N2 subtype. It plays a critical role in viral entry by binding to sialic acid-containing receptors on host cells, facilitating viral attachment and subsequent fusion with the host cell membrane. HA is also a primary target for neutralizing antibodies and thus central to immune recognition and vaccine design. The mature functional form of hemagglutinin exists as a homotrimer, with each monomer composed of HA1 (receptor binding) and HA2 (membrane fusion).
- Other names
- HemagglutininH3N2 HA
02
Mechanism of action
Attachment to sialic acid receptors, pH-dependent conformational change and membrane fusion
03
Biological functions
Receptor bindingMembrane fusionViral entryAntigen presentation
04
Disease associations
InfluenzaViral infection
05
Safety considerations
Antigenic drift leading to vaccine evasionPotential for antibody-dependent enhancement (ADE)
06
Interacting drugs
NA inhibitors (e.g., Oseltamivir, Zanamivir) - indirectly, by preventing viral release
1 more in the full profile.
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