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Target intelligence / Profile preview
Influenza A H7 Hemagglutinin (H7 HA)
- Target
- H7 HA
- Molecular classification
- Glycoprotein, Viral protein, Hemagglutinin
01
Overview
Influenza A H7 hemagglutinin (HA) is a surface glycoprotein essential for viral entry. It mediates attachment to host cells via sialic acid binding and facilitates membrane fusion after endocytosis. H7 HA is a major target for neutralizing antibodies and a key determinant of viral infectivity and pathogenicity. Variations in glycosylation and amino acid sequence contribute to antigenic drift and impact immune recognition.
- Other names
- H7 hemagglutininHA H7Influenza A H7 HA
02
Mechanism of action
Attachment to sialic acid receptors on host cells, followed by pH-dependent conformational change leading to membrane fusion and viral entry. Antibodies can neutralize by blocking receptor binding or fusion.
03
Biological functions
Viral attachment to host cellsMembrane fusionReceptor bindingImmune response elicitation
04
Disease associations
InfectionInfluenzaRespiratory disease
05
Safety considerations
Antigenic drift leading to vaccine escapePotential for pandemic emergenceRisk of antibody-dependent enhancement (ADE) in some cases
06
Interacting drugs
Oseltamivir (targets neuraminidase, but indirectly affects HA)
2 more in the full profile.
07
Biomarkers
Antibody titers against H7 HAH7 HA sequence variations (for strain identification and vaccine matching)
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