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Target intelligence / Profile preview
Influenza A hemagglutinin protein (H3)
- Molecular classification
- Viral surface glycoprotein, Hemagglutinin
01
Overview
Influenza A hemagglutinin (HA) is a trimeric glycoprotein on the surface of influenza viruses, including the H3 subtype. It mediates viral entry by binding to sialic acid receptors on host cells and facilitating fusion of the viral and cellular membranes. HA is a major target for neutralizing antibodies and is a key component of influenza vaccines. Its high variability necessitates frequent vaccine updates.
02
Mechanism of action
Inhibition of receptor binding or membrane fusion by antibodies
03
Biological functions
Receptor bindingMembrane fusionVirus attachmentErythrocyte agglutination
04
Disease associations
InfectionInfluenza
05
Safety considerations
Antigenic drift and shift leading to vaccine escapePotential for antibody-dependent enhancement (ADE) of infection
06
Interacting drugs
Hemagglutinin-targeting antibodies
1 more in the full profile.
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