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Target intelligence / Profile preview
Influenza A Matrix Protein 1 (M1)
- Target
- M1
- Molecular classification
- Structural protein, Matrix protein
01
Overview
Influenza A matrix protein 1 (M1) is a multifunctional structural component essential for influenza virus replication. It orchestrates key steps such as particle assembly/budding by forming an endoskeletal layer under the lipid envelope while mediating interactions among various viral components—including glycoproteins on the surface and internal ribonucleoproteins—and regulating processes like nuclear export through post-translational modifications such as phosphorylation. Its highly ordered structure makes it vital not only to virion stability but also to potential antiviral strategies targeting its unique interfaces or regulatory mechanisms.
- Other names
- Matrix protein 1M1 proteinInfluenza A M1
02
Mechanism of action
Inhibition of M1 oligomerization/assembly (potential)
03
Biological functions
Virion assemblyVirion buddingGenome encapsidationvRNP nuclear exportRegulation of viral transcriptionStructural integrity of virion
04
Disease associations
InfectionInfluenza
05
Safety considerations
Resistance developmentOff-target effects due to conservation with host proteins (potential)
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