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Target intelligence / Profile preview
Influenza A Matrix Protein 2 (M2)
- Target
- M2
- Molecular classification
- Viroporin, Ion channel, Proton channel, Viral protein
01
Overview
The Influenza A M2 protein is a small, integral membrane protein that functions as a proton-selective ion channel (viroporin) in the viral envelope of influenza A virus. It is essential for the viral life cycle, particularly during entry and uncoating within host cells. It forms a homotetramer and its activity is pH-dependent. It is a target for antiviral drugs like amantadine and rimantadine, but drug resistance is a concern.
- Other names
- Influenza A M2 proteinM2 proteinM2 ion channel
02
Mechanism of action
Block proton conduction through direct binding within the transmembrane region.
03
Biological functions
Proton transportViral uncoatingpH regulationVirus assemblyFacilitates viral RNA release
04
Disease associations
InfectionInfluenza A
05
Safety considerations
Drug resistance mutationsLimited clinical utility due to resistance
06
Interacting drugs
Amantadine
1 more in the full profile.
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