Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Influenza A Polymerase Basic Protein 2 (PB2)
- Target
- PB2
- Molecular classification
- Enzyme, RNA-dependent RNA polymerase subunit
01
Overview
Influenza A polymerase basic protein 2 (PB2) is a subunit of the viral RNA-dependent RNA polymerase complex. It is essential for viral transcription and replication. PB2 recognizes and binds to the 5' cap structures of host pre-mRNAs, initiating viral mRNA synthesis through a process called "cap-snatching". Residue K627 is a key determinant of host range and pathogenicity. Some variants can localize to mitochondria and interact with MAVS, potentially modulating immune responses.
02
Mechanism of action
Inhibition of cap-snatching, Inhibition of polymerase complex
03
Biological functions
Transcription initiationCap-snatchingViral mRNA synthesisRNA replicationImmune evasion
04
Disease associations
InfectionInfluenza
05
Safety considerations
Potential for drug resistanceOff-target effects on host cell machinery
Beyond the preview
Go deeper on Influenza A Polymerase Basic Protein 2 (PB2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Influenza A Polymerase Basic Protein 2 (PB2).