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Target intelligence / Profile preview
Influenza A virus H1N1 hemagglutinin (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral envelope protein, Class I fusion protein
01
Overview
Influenza A virus H1N1 hemagglutinin (HA) is a homotrimeric glycoprotein on the viral envelope, synthesized as an inactive precursor HA0 that is cleaved into HA1 and HA2 subunits by host proteases for activation. HA1 forms the globular head containing the receptor binding domain (RBD) that attaches to sialic acid on host cells, while HA2 forms the stalk responsible for low pH-induced conformational changes enabling viral-host membrane fusion in the endosome. The structure includes conserved sialic acid binding residues and antigenic sites prone to variation, influencing vaccine and antibody efficacy.[1][2][5][6]
- Other names
- H1 hemagglutininH1 HAInfluenza A H1N1 HA
02
Mechanism of action
Neutralization of receptor binding domain (head), Inhibition of membrane fusion (stalk-targeting antibodies)
03
Biological functions
Viral attachment to host cellsReceptor binding (sialic acid)Membrane fusionViral entry
04
Disease associations
Infection
05
Safety considerations
Antigenic drift in receptor binding domainGlycosylation changes evading antibodiesSequence insertions affecting antibody binding
06
Interacting drugs
C05 (broadly neutralizing antibody)
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