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Target intelligence / Profile preview
Influenza A Virus Haemagglutinin Protein (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral Protein, Membrane Protein
01
Overview
The haemagglutinin (HA) protein is a homotrimeric glycoprotein found on the surface of influenza A viruses. It is essential for viral infectivity, mediating both the initial attachment of the virus to host cells and subsequent membrane fusion required for viral entry. HA is the major surface antigen and a primary target for neutralizing antibodies. Antigenic variation in HA leads to seasonal epidemics and pandemics.
- Other names
- HemagglutininHA proteinH1H3H5H7
02
Mechanism of action
Antibodies against HA neutralize the virus by blocking receptor binding or inhibiting membrane fusion.
03
Biological functions
Receptor bindingMembrane fusionViral entryHost cell attachmentAntigen presentation
04
Disease associations
InfluenzaViral infectionRespiratory diseasePandemic
05
Safety considerations
Antigenic driftAntigenic shiftImmune evasionStrain variabilityPotential for zoonotic transmission
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