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Influenza A virus Hemagglutinin protein subtype H7
- Molecular classification
- Viral envelope glycoprotein, Receptor
01
Overview
The hemagglutinin (HA) protein is a major surface glycoprotein of the influenza A virus, responsible for binding to host cell receptors and mediating viral entry. The H7 subtype refers to one of the 18 known HA subtypes in influenza A viruses. The H7 hemagglutinin is particularly relevant due to its association with avian influenza outbreaks and occasional zoonotic transmission to humans. It binds sialic acid-containing receptors on host cells and undergoes conformational changes to trigger membrane fusion.
- Other names
- H7 hemagglutininH7 HA
02
Mechanism of action
Neutralizing antibodies block attachment and membrane fusion
03
Biological functions
Host cell attachmentMembrane fusionViral entry
04
Disease associations
Infection
05
Safety considerations
Potential for antigenic drift and shift leading to vaccine escapeZoonotic potential (avian to human transmission)
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