Target intelligence / Profile preview

Influenza A Virus M2 Protein (M2)

Target: M2
Molecular classification: Viroporin, Ion channel

Overview

The M2 protein of the influenza A virus is a small, integral membrane protein that functions as a proton-selective ion channel (viroporin) in the viral envelope. It is essential for multiple stages of the viral life cycle, including entry, uncoating, assembly, and budding. The primary role of M2 is to act as a pH-gated proton channel, facilitating proton influx into the virion to promote uncoating and prevent premature hemagglutinin activation. Its ion channel activity makes it a target for antiviral drugs such as amantadine and rimantadine.

Mechanism of action

Blocks proton conductance by binding within the transmembrane pore.

Biological functions

Proton transportViral uncoatingViral assemblyViral budding

Disease associations

Infection

Safety considerations

Drug resistance mutations

Interacting drugs

Amantadine

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