Target intelligence / Profile preview

Influenza A Virus Matrix Protein 1 (M1)

Target: M1
Molecular classification: Structural protein, Matrix protein

Overview

The Influenza A virus M1 protein is the most abundant structural protein in influenza virions. It forms a matrix layer directly beneath the viral lipid envelope, playing a central role in maintaining virion integrity and mediating multiple steps of the viral life cycle. It is essential for assembly at the plasma membrane; its oligomerization drives budding and formation of new virus particles. M1 shuttles between nucleus and cytoplasm during infection and represents an attractive target for antiviral strategies against influenza viruses.

Mechanism of action

Unknown

Biological functions

Virion structure and integrityViral assembly and buddingRNA bindingvRNP exportTranscription inhibition

Disease associations

Infection

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