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Target intelligence / Profile preview
Influenza A Virus Neuraminidase Protein N1 Subtype (NA N1)
- Target
- NA N1
- Molecular classification
- Enzyme, Viral Protein, Glycoprotein
01
Overview
The neuraminidase (NA) protein is a surface glycoprotein of influenza A viruses, specifically the N1 subtype in this case. NA is crucial for viral release by cleaving sialic acid residues, facilitating spread to new host cells. Its globular head domain contains antigenic sites susceptible to antigenic drift. It is a target for antiviral drugs like oseltamivir and zanamivir, although resistance can emerge.
- Other names
- N1 NeuraminidaseFlu A NA N1Influenza A NA N1N1 subtype neuraminidase
02
Mechanism of action
Neuraminidase inhibitors that block the active site of the enzyme, preventing viral release and spread.
03
Biological functions
Viral ReleaseSialic Acid CleavagePrevention of Viral AggregationVirus Dissemination
04
Disease associations
InfectionInfluenzaViral Pathogenesis
05
Safety considerations
Drug resistance via point mutationsPotential for reduced efficacy due to antigenic driftAdverse drug reactions (related to specific inhibitors)
06
Interacting drugs
Oseltamivir
1 more in the full profile.
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