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Target intelligence / Profile preview
Influenza B Hemagglutinin Antigen (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral protein, Surface antigen
01
Overview
Influenza B hemagglutinin (HA) is the major surface glycoprotein and principal antigen of the influenza B virus. It plays a critical role in viral entry by binding to host cell receptors and mediating membrane fusion, making it essential for infection and a primary target for neutralizing antibodies. HA exists as a homotrimer, with each monomer composed of two subunits: HA1 (membrane-distal, globular head) and HA2 (membrane-proximal, stem domain).
- Other names
- HemagglutininInfluenza B HAHA proteinInfluenza B Virus Hemagglutinin
02
Mechanism of action
Antibody neutralization of receptor binding or membrane fusion
03
Biological functions
Receptor bindingMembrane fusionViral entryAntigen presentation
04
Disease associations
InfectionInfluenza B
05
Safety considerations
Antigenic drift leading to vaccine escapeStrain-specific immunity
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