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Target intelligence / Profile preview
Influenza B Hemagglutinin Protein (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral Surface Protein
01
Overview
The influenza B hemagglutinin (HA) protein is a homotrimeric glycoprotein found on the surface of influenza B viruses. It is essential for viral infectivity, mediating both the initial attachment to host cells and subsequent membrane fusion required for viral entry. The HA protein exists as a trimer, with each monomer composed of two subunits: HA1 and HA2. The globular head contains the receptor-binding site (RBS), which interacts with sialic acid-containing receptors on host cells. Antigenic drift occurs through amino acid substitutions—especially within or near key epitopes—enabling escape from pre-existing immunity.
- Other names
- HemagglutininInfluenza B HA
02
Mechanism of action
N/A
03
Biological functions
Receptor bindingMembrane fusionViral entry
04
Disease associations
InfectionInfluenza
05
Safety considerations
Antigenic drift leading to vaccine escapePotential for antibody-dependent enhancement (ADE)
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