Influenza B nucleoprotein (NP (for nucleoprotein))

Influenza B nucleoprotein is the primary structural and functional component of the viral ribonucleoprotein (RNP) complex in Influenza B viruses, essential for viral RNA encapsidation and for the regulation of both transcription and replication of the viral genome[1][2][4]. It forms homo-oligomers through tail-loop insertions, binds viral RNA in an electropositive groove, and shuttles the RNP complex into the host nucleus via a nuclear localization signal located in its extended N-terminal region[1][2][3]. The nucleoprotein is highly conserved within influenza B viruses but possesses an N-terminal extension distinguishing it from influenza A nucleoprotein, and this extension is critical for viral viability and nuclear import[2][3]. Because of its central role in viral replication, it is an attractive target for antiviral drug development and a reliable diagnostic marker for infection[2].

Other names

Influenza B virus nucleoproteinInfluenza B NPBNP

Inhibition of nucleoprotein blocks viral RNA encapsidation, thereby impairing genome replication and transcription[1][2] - Disruption of nuclear import prevents replication complex assembly[3]