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Target intelligence / Profile preview
Influenza B virus hemagglutinin (HA)
- Target
- HA
- Molecular classification
- Viral protein, Glycoprotein, Fusion protein, Surface antigen
01
Overview
Influenza B virus hemagglutinin is an essential trimeric surface glycoprotein responsible for both binding host cell receptors via its globular head domain and mediating pH-dependent membrane fusion through its stem region. While structurally similar to its counterpart in Influenza A viruses, it exhibits unique features influencing species specificity and displays reduced capacity for antigenic variation due to lower mutational tolerance—factors relevant both biologically and clinically as targets for immunity-based interventions such as vaccines.
- Other names
- HemagglutininHA proteinInfluenza B HA
02
Mechanism of action
Neutralizing antibodies block receptor binding or membrane fusion
03
Biological functions
Viral attachmentMembrane fusionReceptor bindingImmune response elicitation
04
Disease associations
InfectionInfluenza B virus infection
05
Safety considerations
Antigenic driftDevelopment of resistance to neutralizing antibodiesPotential for off-target effects with antibody-based therapies
06
Interacting drugs
NA inhibitors (indirectly, by preventing viral release)
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