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Target intelligence / Profile preview
Influenza B Virus Hemagglutinin Protein (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral protein, Surface protein
01
Overview
The hemagglutinin (HA) protein of the Influenza B virus is a major surface glycoprotein essential for viral entry into host cells. It mediates both the binding of the virus to host cell receptors and the subsequent fusion of viral and cellular membranes, enabling infection. HA exists as a homotrimer, with each monomer containing a globular head domain for receptor binding and a stem domain for membrane fusion. Frequent mutations at key epitopes lead to antigenic drift, impacting vaccine design.
- Other names
- HemagglutininHA proteinInfluenza B HA
02
Mechanism of action
Receptor binding to sialic acid residues on host cells; pH-dependent conformational change leading to membrane fusion.
03
Biological functions
Receptor bindingMembrane fusionViral entryHost cell attachment
04
Disease associations
InfectionInfluenzaViral pathogenesis
05
Safety considerations
Antigenic drift leading to vaccine mismatchPotential for resistance to HA-targeting therapeuticsRisk of immune escape mutations
06
Interacting drugs
NA inhibitors (e.g., Oseltamivir, Zanamivir) - indirectly by preventing viral release
2 more in the full profile.
07
Biomarkers
HA sequence variations as markers of antigenic driftAntibody titers against HA as correlate of protection
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