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Target intelligence / Profile preview
Influenza B Virus Hemagglutinin Protein (Yamagata Lineage) (HA (Yamagata))
- Target
- HA (Yamagata)
- Molecular classification
- Viral Protein, Glycoprotein, Hemagglutinin
01
Overview
The hemagglutinin (HA) protein of the Influenza B virus (Yamagata lineage) is a surface glycoprotein essential for viral entry, mediating attachment to host cells and subsequent membrane fusion. It is a major target for neutralizing antibodies and vaccine development due to its immunodominant epitopes and role in infection.
- Other names
- Hemagglutinin (Yamagata lineage)Influenza B HA (Yamagata)HA protein (Yamagata)
02
Mechanism of action
Targeted by neutralizing antibodies that block receptor binding or prevent conformational changes required for membrane fusion.
03
Biological functions
Receptor bindingMembrane fusionViral entryImmune evasion
04
Disease associations
InfectionInfluenzaRespiratory disease
05
Safety considerations
Antigenic drift leading to vaccine mismatchPotential for escape mutantsImmunogenicity issues
06
Interacting drugs
Anti-influenza antibodies
2 more in the full profile.
07
Biomarkers
HA antibody titers (vaccine efficacy)HA sequence (antigenic drift monitoring)HA expression levels (viral load)
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