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Influenza B virus hemagglutinin Yamagata lineage antigen
- Molecular classification
- Surface glycoprotein, Viral protein
01
Overview
The hemagglutinin (HA) of the Influenza B virus Yamagata lineage is a surface glycoprotein that mediates viral entry into host cells and is a primary antigenic determinant distinguishing this lineage. It is a major target for neutralizing antibodies and thus central to immune recognition and vaccine design. The Yamagata lineage is antigenically distinct, and while once included in quadrivalent vaccines, natural occurrences have been unconfirmed since March 2020.
- Other names
- HA (Yamagata lineage)Yamagata HAB/Yamagata hemagglutininInfluenza B Yamagata HA
02
Mechanism of action
Neutralization of viral entry by antibody binding to HA
03
Biological functions
Viral attachmentMembrane fusionImmune response induction
04
Disease associations
InfectionInfluenza
05
Safety considerations
Potential for antigenic driftRisk of vaccine mismatch if circulating strains differ from vaccine strains
06
Interacting drugs
Influenza vaccines
1 more in the full profile.
07
Biomarkers
Antibody titers against Yamagata HAHA sequence variants (for strain identification)
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