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Target intelligence / Profile preview
Influenza Hemagglutinin Antigen (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral Surface Protein
01
Overview
Influenza hemagglutinin (HA) is a trimeric glycoprotein on the surface of influenza viruses. It binds to sialic acid receptors on host cells, initiating infection and facilitating membrane fusion. HA is a key antigen and the primary target for neutralizing antibodies.
02
Mechanism of action
Neutralizing antibodies block receptor binding or membrane fusion
03
Biological functions
Receptor bindingMembrane fusionViral entry
04
Disease associations
InfectionInfluenza
05
Safety considerations
Antigenic drift leading to reduced vaccine efficacyAntigenic shift leading to pandemics
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