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Target intelligence / Profile preview
Influenza Hemagglutinin Protein (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral protein, Surface protein
01
Overview
Influenza hemagglutinin (HA) is a surface glycoprotein on influenza viruses. It mediates receptor binding to sialic acid on host cells and subsequent membrane fusion, enabling viral entry. HA is a major target for neutralizing antibodies and is the primary antigen used in influenza vaccines. Its antigenic variability necessitates frequent vaccine updates to match circulating strains.
- Other names
- HemagglutininHA proteinHAH1H3
02
Mechanism of action
Neutralization of viral entry by blocking receptor binding or membrane fusion
03
Biological functions
Receptor bindingMembrane fusionViral entryHemagglutination
04
Disease associations
InfluenzaViral infectionRespiratory disease
05
Safety considerations
Antigenic variability leading to vaccine mismatchPotential for escape mutantsRisk of vaccine-associated adverse events (rare)
06
Interacting drugs
Influenza vaccines
1 more in the full profile.
07
Biomarkers
HA antibody titers (for vaccine efficacy)HA sequence (for strain identification and vaccine matching)
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