Target intelligence / Profile preview

Influenza Matrix Protein (M1)

Target: M1
Molecular classification: Structural Protein, Viral Protein

Overview

The influenza matrix protein, M1, is the most abundant structural protein in influenza virions. It forms a layer beneath the viral envelope and plays crucial roles in viral assembly, budding, disassembly during cell entry, and vRNP export from the nucleus. M1 interacts with vRNPs, viral glycoproteins, and host cell membranes, making it a key component in the influenza virus life cycle. Targeting M1 could disrupt viral replication, but resistance and off-target effects pose potential challenges.

Mechanism of action

Inhibition of M1 function to disrupt viral assembly/disassembly

Biological functions

Virion AssemblyViral BuddingvRNP ExportRNA BindingVirion StabilizationGenome Release

Disease associations

InfectionInfluenza

Safety considerations

Potential for resistance development if targeting M1 directlyOff-target effects due to interactions with host cell proteins

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