Target intelligence / Profile preview

Influenza Matrix Protein 1 (M1)

Target: M1
Molecular classification: Viral structural protein, Matrix protein

Overview

Influenza matrix protein 1 (M1) is the most abundant structural protein in influenza A virions. It forms a continuous layer beneath the viral lipid envelope, acting as an endoskeleton that is essential for multiple stages of the virus life cycle, including assembly, budding, disassembly during entry into new host cells, and regulation of viral ribonucleoprotein (vRNP) trafficking.

Other names: Matrix protein 1M1 protein

Mechanism of action

Disruption of M1 function leads to impaired viral assembly and budding.

Biological functions

Virion structure/endoskeletonVirus assemblyVirus buddingvRNP exportTranscription inhibitionGenome encapsidation

Disease associations

Infection

Safety considerations

Targeting M1 could potentially lead to drug resistance due to viral mutations.

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