Target intelligence / Profile preview

Influenza Neuraminidase (NA)

Target: NA
Molecular classification: Enzyme, Glycoprotein, Exosialidase

Overview

Influenza neuraminidase (NA) is a surface glycoprotein enzyme found on the influenza virus. It plays a critical role in the viral life cycle, particularly in the release and spread of progeny viruses from infected host cells. NA is an exosialidase (EC 3.2.1.18) that cleaves terminal sialic acid residues from glycan structures on both host cell surfaces and viral proteins, facilitating efficient viral dissemination. It is a major target for anti-influenza drugs.

Mechanism of action

Neuraminidase inhibitors bind to the active site of neuraminidase, preventing the cleavage of sialic acid and thus inhibiting the release of new virions from infected cells.

Biological functions

Viral releaseViral spreadSialic acid cleavage

Disease associations

InfectionInfluenza

Safety considerations

Drug resistance (e.g., Oseltamivir resistance due to H274Y mutation)

Interacting drugs

Zanamivir

2 more in the full profile.

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