Target intelligence / Profile preview

Influenza Neuraminidase Antigen (NA)

Target: NA
Molecular classification: Enzyme, Viral Glycoprotein

Overview

Influenza neuraminidase (NA) is a surface glycoprotein antigen found on influenza viruses, including both influenza A and B strains. It is an exosialidase enzyme that cleaves terminal sialic acid residues, which is essential for viral release from infected cells and subsequent spread. NA is a major target for antiviral drugs and a potential component of next-generation influenza vaccines.

Other names: NeuraminidaseSialidase

Mechanism of action

Inhibition of neuraminidase enzyme activity, preventing virion release from infected cells.

Biological functions

Viral ReleaseViral SpreadSialic Acid Cleavage

Disease associations

InfectionInfluenza

Safety considerations

Drug resistance due to mutations in the neuraminidase geneMaintaining protein stability during vaccine production

Interacting drugs

Oseltamivir

2 more in the full profile.

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