Target intelligence / Profile preview

Influenza Nucleoprotein (NP)

Target: NP
Molecular classification: Structural protein, RNA-binding protein

Overview

Influenza nucleoprotein (NP) is a major structural protein in influenza virus particles that performs multiple critical functions in the viral infectious cycle. As one of the most abundantly expressed proteins during infection, NP plays essential roles in viral RNA synthesis, genome organization, and viral replication. It is a promising druggable target for antiviral development.

Mechanism of action

NP aggregation and inhibition of nuclear accumulation

Biological functions

RNA bindingRNP formationTranscription regulationReplication regulationNuclear transportStructural support

Disease associations

Infection

Interacting drugs

Nucleozin

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