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Target intelligence / Profile preview
Influenza polymerase basic protein 1 (PB1)
- Target
- PB1
- Molecular classification
- Enzyme, RNA-dependent RNA polymerase
01
Overview
Influenza polymerase basic protein 1 (PB1) is a core subunit of the influenza virus RNA-dependent RNA polymerase complex, essential for viral genome replication and transcription. PB1 acts as the catalytic subunit of the heterotrimeric polymerase complex and is responsible for catalyzing the synthesis of viral RNAs.
02
Mechanism of action
RdRp inhibition
03
Biological functions
RNA replicationmRNA transcriptionViral genome replication
04
Disease associations
Infection
05
Safety considerations
Potential for resistance mutations
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