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Target intelligence / Profile preview
Influenza Polymerase Basic Protein 2 (PB2)
- Target
- PB2
- Molecular classification
- Enzyme, RNA-dependent RNA polymerase subunit, Transcription factor
01
Overview
Influenza polymerase basic protein 2 (PB2) is a subunit of the heterotrimeric RNA-dependent RNA polymerase complex (FluPol) essential for influenza virus replication and transcription. It binds to the 5' cap structure of host pre-mRNAs, enabling "cap-snatching" to prime viral mRNA synthesis. The residue at position 627 is a critical determinant for host range and pathogenicity. PB2 also plays a role in modulating the host immune response by targeting mitochondria.
02
Mechanism of action
Inhibition of viral RNA transcription and replication by blocking cap-snatching or disrupting polymerase complex formation.
03
Biological functions
Viral RNA transcriptionViral RNA replicationCap-snatchingHost mRNA bindingImmune evasion
04
Disease associations
InfectionInfluenza
05
Safety considerations
Potential for drug resistance due to mutations in PB2.Off-target effects on host cell transcription.
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