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Target intelligence / Profile preview
Influenza RNA Polymerase Complex (FluPol)
- Target
- FluPol
- Molecular classification
- Enzyme, RNA-dependent RNA polymerase, Polymerase complex
01
Overview
The influenza RNA polymerase complex (FluPol) is a heterotrimeric enzyme essential for influenza virus replication and transcription. It consists of three subunits, PB1, PB2, and PA, each contributing to its function. PB1 is the core transcriptase, PB2 binds to capped RNA primers, and PA possesses endonuclease activity for "cap-snatching." FluPol is a prime target for antiviral drugs due to its indispensable role in the viral life cycle.
- Other names
- Influenza polymeraseViral RNA polymerasePB1-PB2-PA complex
02
Mechanism of action
Inhibition of viral RNA synthesis; disruption of cap-snatching; inhibition of polymerase activity
03
Biological functions
RNA transcriptionRNA replicationCap-snatchingPolyadenylationViral genome expression
04
Disease associations
InfectionInfluenza
05
Safety considerations
Potential for drug resistanceOff-target effects on host cell polymerases
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