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Target intelligence / Profile preview
Influenza Virus Cap-dependent Endonuclease (PA-N domain) (PA-N)
- Target
- PA-N
- Molecular classification
- Enzyme, Viral protein, Endonuclease
01
Overview
The influenza virus RNA polymerase complex contains a cap-dependent endonuclease located in the N-terminal domain of the PA subunit (PA-N). This enzyme is essential for viral mRNA synthesis via a "cap-snatching" mechanism, where it cleaves host pre-mRNAs to generate capped RNA primers. PB2 subunit binds the cap, PA subunit cleaves the RNA. This activity is a validated antiviral drug target.
- Other names
- Influenza Virus RNA Polymerase PA subunit (N-terminal domain)PA endonucleaseCap-snatching endonucleaseInfluenza PA-NPA N-terminal domain
02
Mechanism of action
Inhibition of endonucleolytic cleavage of host capped RNAs
03
Biological functions
Viral mRNA synthesisCap-snatchingRNA cleavagePrimer generation
04
Disease associations
InfectionInfluenza
05
Interacting drugs
Baloxavir marboxil
1 more in the full profile.
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