Target intelligence / Profile preview

Influenza Virus Haemagglutinin (B Strain) (HA (Influenza B))

Target
HA (Influenza B)
Molecular classification
Glycoprotein, Viral protein, Surface protein
01

Overview

Influenza virus haemagglutinin (HA) is the major surface glycoprotein of the influenza B virus, comprising over 80% of the envelope proteins in the viral particle. HA plays a critical role in viral entry by mediating binding to host cell receptors and facilitating membrane fusion. The protein is also a primary target for neutralizing antibodies and thus central to immune recognition and vaccine design.

Other names
Hemagglutinin (Influenza B)HAInfluenza B Hemagglutinin
02

Mechanism of action

Neutralization of HA prevents viral entry into host cells; inhibition of receptor binding or membrane fusion

03

Biological functions

Receptor bindingMembrane fusionViral entryImmune recognition
04

Disease associations

InfectionInfluenza
05

Safety considerations

Antigenic drift leading to vaccine escapePotential for antibody-dependent enhancement (ADE)

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