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Target intelligence / Profile preview
Influenza Virus Hemagglutinin and Neuraminidase Proteins (HA and NA)
- Target
- HA and NA
- Molecular classification
- Glycoprotein, Viral protein, Enzyme (Neuraminidase), Receptor (Hemagglutinin)
01
Overview
Hemagglutinin (HA) and neuraminidase (NA) are two major surface glycoproteins of the influenza virus, playing essential roles in viral infectivity, transmission, and immune recognition. Hemagglutinin mediates viral entry by binding to sialic acid receptors and facilitating membrane fusion. Neuraminidase facilitates viral release by cleaving sialic acid residues. Both proteins are major targets for antiviral drugs and vaccines.
- Other names
- HemagglutininNeuraminidaseHANAInfluenza HAInfluenza NA
02
Mechanism of action
Neuraminidase inhibitors block the activity of neuraminidase, preventing the release of new virions from infected cells.
03
Biological functions
Viral entryViral releaseReceptor bindingMembrane fusionSialic acid cleavageImmune evasion
04
Disease associations
InfectionInfluenzaEpidemicsPandemics
05
Safety considerations
Antigenic driftAntigenic shiftResistance to antiviral drugs
06
Interacting drugs
Oseltamivir
1 more in the full profile.
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