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Influenza virus hemagglutinin antigen
- Molecular classification
- Class I viral fusion proteins, Glycoprotein
01
Overview
Hemagglutinin (HA) is the major surface glycoprotein of influenza viruses, mediating viral attachment to host cells and subsequent membrane fusion. It is a homotrimeric protein composed of HA1 and HA2 subunits. HA is a primary target for neutralizing antibodies and is crucial for viral entry, making it a key target for vaccine and therapeutic development. Its high variability due to antigenic drift and shift poses a significant challenge for achieving broad and long-lasting immunity.
- Other names
- HAHemagglutinin
02
Mechanism of action
Attachment inhibition (e.g., by antibodies), fusion inhibition (e.g., by fusion inhibitors)
03
Biological functions
Receptor bindingMembrane fusionViral entryAntigen presentationImmune response
04
Disease associations
InfectionInfluenza
05
Safety considerations
Antigenic drift leading to vaccine escapeAntigenic shift leading to pandemic potentialStrain-specific immunity
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