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Influenza Virus Hemagglutinin Protein (HA)
- Target
- HA
- Molecular classification
- Viral Surface Glycoprotein
01
Overview
Influenza virus hemagglutinin (HA) is a major surface glycoprotein found on the envelope of influenza viruses. It is essential for viral infectivity, mediating both the initial attachment of the virus to host cells and subsequent fusion of viral and cellular membranes. HA is a homotrimeric protein, with each monomer cleaved into HA1 and HA2 subunits. It functions in receptor binding to sialic acid on host cells and mediates membrane fusion after endocytosis. Antigenic variation in HA underlies seasonal epidemics and pandemics. HA is a key target for neutralizing antibodies and vaccine design.
- Other names
- HemagglutininHA proteinH protein
02
Mechanism of action
Inhibition of receptor binding; Inhibition of membrane fusion
03
Biological functions
Receptor bindingMembrane fusionViral entryAntigen
04
Disease associations
InfectionInfluenza
05
Safety considerations
Antigenic variation (drift and shift)Potential for antibody-dependent enhancement (ADE) of infection
06
Interacting drugs
Monoclonal antibodies (e.g., broadly neutralizing antibodies)
1 more in the full profile.
07
Biomarkers
HA antibody titers (vaccine efficacy)HA sequence (strain identification)
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