Target intelligence / Profile preview

Influenza Virus Hemagglutinin Protein H3N2 Subtype (H3N2 HA)

Target: H3N2 HA
Molecular classification: Viral Protein, Glycoprotein, Type I transmembrane protein

Overview

The hemagglutinin (HA) protein of the influenza A virus H3N2 subtype is a trimeric glycoprotein on the viral envelope responsible for receptor binding and membrane fusion during host cell entry. It is a major target for neutralizing antibodies and the primary component of influenza vaccines. The HA protein evolves rapidly through antigenic drift, requiring frequent updates to vaccine formulations.

Other names: H3N2 HemagglutininHA H3N2

Mechanism of action

Mediates viral entry into host cells via receptor binding and membrane fusion. Vaccines elicit neutralizing antibodies that block this process.

Biological functions

Receptor bindingMembrane fusionViral entryAntigen presentation

Disease associations

InfectionInfluenzaRespiratory disease

Safety considerations

Antigenic drift leading to vaccine mismatchPotential for novel reassortment eventsEfficacy varies based on circulating strains

Interacting drugs

Oseltamivir (indirectly, by preventing release of new virions)

2 more in the full profile.

Biomarkers

Antibody titers against H3N2 HA (vaccine efficacy, prior exposure)HA sequence variants (antigenic drift, vaccine matching)

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