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Target intelligence / Profile preview
Influenza Virus Neuraminidase (NA)
- Target
- NA
- Molecular classification
- Glycoside hydrolase, Enzyme
01
Overview
Influenza virus neuraminidase (NA) is a surface glycoprotein enzyme found on the envelope of influenza A and B viruses. It plays a critical role in the viral life cycle, particularly in the release and spread of progeny virions from infected host cells. NA acts as an exosialidase, cleaving terminal sialic acid residues from glycoproteins and glycolipids on host cell surfaces and viral proteins, facilitating virion release and movement through mucus. It is a key target for antiviral drugs like zanamivir and oseltamivir, which inhibit its enzymatic activity.
- Other names
- SialidaseExosialidase
02
Mechanism of action
Competitive inhibition of neuraminidase active site
03
Biological functions
Virion releaseSialic acid cleavageViral spreadMucus penetration
04
Disease associations
Infection
05
Safety considerations
Drug resistance (e.g., H274Y mutation)Potential for reduced viral fitness with resistance mutations
06
Interacting drugs
Zanamivir
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