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Influenza virus RNA polymerase

Molecular classification: Enzyme, RNA-dependent RNA polymerase

Overview

The influenza virus RNA polymerase is a heterotrimeric, RNA-dependent RNA polymerase complex essential for the transcription and replication of the viral genome. It is composed of three subunits: PB1, PB2, and PA (or P3 in influenza C/D). PB1 is the catalytic subunit, PB2 binds to host mRNA caps, and PA/P3 possesses endonuclease activity. The polymerase is crucial for viral mRNA synthesis and genome replication, making it a central target for antiviral drug development.

Mechanism of action

Inhibition of viral RNA polymerase activity

Biological functions

TranscriptionReplicationmRNA synthesis

Disease associations

Infection

Safety considerations

Development of resistance mutations

Interacting drugs

Favipiravir

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