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Target intelligence / Profile preview
Inhibin Beta E Subunit (INHBE)
- Target
- INHBE
- Molecular classification
- TGF-β superfamily member, Growth factor
01
Overview
INHBE encodes the inhibin beta E subunit, a member of the transforming growth factor-beta (TGF-β) superfamily. It is involved in regulating diverse physiological processes such as cell proliferation, apoptosis, immune response, hormone secretion, and reproductive physiology. INHBE forms activins and inhibins that affect FSH secretion and may have tissue-specific roles in endometrial maturation and cancer.
- Other names
- Inhibin beta E chain
02
Mechanism of action
Inhibins compete with activin for receptor binding or interact with inhibin-specific receptors, antagonizing activin signaling and FSH release.
03
Biological functions
Regulation of FSH secretionCell proliferationApoptosisImmune responseEndometrial maturationReproductive tissue functionRegulation of gene expression
04
Disease associations
CancerReproductive disorders
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