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Target intelligence / Profile preview
Inhibin subunit beta E (INHBE)
- Target
- INHBE
- Molecular classification
- Growth factor, Cytokine, Secreted protein, TGF-beta superfamily
01
Overview
Inhibin subunit beta E is a protein encoded by the INHBE gene, primarily expressed in the liver and belonging to the transforming growth factor-beta (TGF-beta) superfamily[2][7]. It forms part of activin E, a hepatokine that acts as a secreted cytokine, regulating diverse biological pathways including hormone secretion at the hypothalamic-pituitary axis and metabolic homeostasis[1][4][7]. INHBE variants have been linked to reduced abdominal fat distribution and lower risk of cardiometabolic disease, suggesting a therapeutic potential for obesity-related conditions[1]. INHBE is upregulated by interferon-beta1a in carcinoma cell lines, and alterations in its expression may affect processes such as insulin resistance and cell proliferation[5][6].
- Other names
- Activin beta Einhibin beta-Einhibin subunit β Einhibin β-E
02
Biological functions
Regulation of hormone secretionSignal transductionRegulation of fat distributionPossible role in energy metabolism
03
Disease associations
Abdominal obesityInsulin resistanceCardiometabolic diseaseCancer (expression regulation in carcinoma cell lines)
04
Safety considerations
Potential metabolic and endocrine side effects due to hormone-regulatory rolesunknown long-term safety of targeting
05
Biomarkers
Lower waist-hip ratio adjusted for BMI (WHRadjBMI) associated with certain loss-of-function variantspossible biomarker for hepatic expression in certain metabolic phenotypes
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