Inhibitor of Apoptosis Protein cIAP2 (cIAP2)

cIAP2 (cellular inhibitor of apoptosis protein 2), also known as HIAP1 or BIRC3, is a member of the inhibitor of apoptosis protein (IAP) family. It functions as a potent suppressor of apoptotic cell death and plays critical roles in regulating immune responses, inflammation, and cell survival. It directly inhibits pro-apoptotic caspases such as caspase-3 to prevent apoptosis and regulates cell survival by targeting pro-apoptotic proteins for ubiquitin-mediated degradation via its E3 ligase activity. cIAP2 expression is highly inducible by NFκB following various triggers such as cytokines or pathogen-associated molecular patterns. Because cIAPs regulate key checkpoints between life/death decisions in cells—especially under stress or inflammatory conditions—they are considered potential therapeutic targets in cancer, autoimmunity/inflammation and infectious diseases.

Other names

HIAP1BIRC3c-IAP2

Promoting cancer cell death through reactivation of apoptotic pathways by inhibiting cIAP1/cIAP2.