Inhibitor of growth protein 4 (ING4)

Inhibitor of growth protein 4 (ING4) is a member of the ING family of tumor suppressor proteins, encoded by the *ING4* gene in humans[1][2]. ING4 contains a plant homeodomain (PHD finger) typical of proteins involved in chromatin remodeling and transcriptional regulation. It interacts with transcription factors such as TP53 and NF-κB, histone acetyltransferase p300/EP300, and is implicated in key cellular processes including cell cycle arrest, apoptosis, autophagy, and suppression of angiogenesis[2][5][6]. Loss or reduced expression of ING4 is associated with various human cancers and fibrotic diseases, linking it to cancer progression, control of cell proliferation, and tissue remodeling in fibrosis[3][6]. Experimental delivery of ING4 suppresses tumor growth in models, but there are currently no approved drugs specifically targeting this protein[4][6].

Other names

ING4inhibitor of growth family member 4tumor suppressor ING4

No clinically validated drugs; experimental gene delivery of ING4 suppresses tumors via cell cycle arrest, apoptosis, and inhibition of NF-κB and HIF pathways[4][6]