Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma pseudogene 1 (IKBKGP1)

IKBKGP1 is a pseudogene in the human genome, with sequence similarity to the IKBKG gene that encodes the NF-kappa-B essential modulator (NEMO) protein. Pseudogenes do not produce functional proteins and typically do not have direct roles in biological processes or disease. IKBKGP1 is not considered a therapeutic target, and its identification should not be confused with NEMO/IKK-γ/IKBKG, which is an important regulatory subunit in the IKK complex that activates NF-κB, impacting inflammation, immune response, and cell survival[5]. Critical note: The terms "deltaNEMO," "IKBKGP," etc., are sometimes used in literature to refer to protein isoforms or variants of the active IKBKG gene (NEMO) related to immune and inflammatory syndromes[2][3], but IKBKGP1 (as a pseudogene) itself is not the functional protein or an actionable drug target. Recommendation: If the intent is to target NEMO/IKK-γ, the accurate target should be "Inhibitor of kappa light polypeptide gene enhancer in B-cells kinase gamma" (IKBKG, also known as NEMO), not the pseudogene IKBKGP1[1][3][5].

Other names

IKBKGPdeltaNEMODelta NEMOInhibitor of nuclear factor kappa B kinase subunit gamma pseudogene 1Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma pseudogene 1IKBKGP1